Thursday, August 7th, 2025

Injectable Moisturiser vs Polynucleotide Skin Treatment: Which Suits Your Skin Goals?

If you’re exploring non-surgical options to improve your skin quality, you may have come across two popular injectables: hydrating injectable moisturisers and polynucleotide skin repair treatments.

Though often used for similar concerns like dull skin, fine lines, or early ageing, they work in distinct ways and are suited for different skin needs.

This guide compares their functions, benefits, treatment areas, and considerations—so you can make an informed choice with your aesthetic provider.

🔗 Learn more about injectable moisturisers here
🔗 Discover more about polynucleotide repair treatments here

Contents hide

1) What are Injectable Moisturisers?

2) What are Polynucleotide (PN) Skin Healer?

3) Comparison Table: Hydrating vs Regenerating Injectables

4) Which Treatment Is More Suitable for You?

5) Differences in Composition

6) Differences in Procedure

7) Differences in Ideal Candidate

8) Differences in Side Effects

9) Can both treatments be used together?

9.1) How Do They Complement Each Other?

10) Frequently Asked Questions

10.1) ⚠️ Disclaimer

What are Injectable Moisturisers?

Injectable moisturisers are stabilised hyaluronic acid (HA) formulations designed to improve hydration, skin elasticity, and overall skin texture.

They are injected in small amounts across broad areas of the face or neck, working gradually to support collagen and skin firmness.

These treatments are commonly chosen by individuals looking to improve glow, reduce skin laxity, or enhance hydration from within.

What are Polynucleotide (PN) Skin Healer?

Polynucleotide (PN) treatments are bio-compatible injectables derived from DNA fragments.

Their primary role is to promote skin healing, support the skin barrier, and stimulate cell regeneration. Often used for sensitive, damaged, or inflamed skin, they are favoured for their restorative properties.

They are commonly applied in areas affected by acne scars, pigmentation, or weakened skin structure.

Key Differences in Composition

HA Injectable Moisturiser: Composed of 100% pure hyaluronic acid, it primarily acts as a hydrator and stimulator for collagen and elastin.
Polynucleotide Skin Healer: Made from salmon DNA polynucleotides that directly stimulate cellular repair and promote anti-inflammatory effects in the skin.

Comparison Table: Hydrating vs Regenerating Injectables

Feature	Injectable Moisturiser	Polynucleotide Treatment
Main Function	Hydration and collagen support	Skin repair and regeneration
Key Ingredient	Stabilised hyaluronic acid	Polynucleotides (DNA fragments)
Best For	Dry, dull, or ageing skin needing hydration and firmness	Sensitive or damaged skin needing healing and repair
Treatment Frequency	2 sessions (4 weeks apart) + maintenance every 6 months	3–4 sessions (2–4 weeks apart), then as needed
Application Areas	Face, neck, hands, under-eye	Cheeks, under-eye, forehead, acne-prone areas
Expected Results	Improved glow, smoother texture, firmer skin	More even tone, less redness, stronger skin barrier

Which Treatment Is More Suitable for You?

The right option depends on your skin concerns:

If your skin is dehydrated, sagging, or lacking elasticity, hydration-based injectables may support skin density and glow.
If your skin is recovering from damage, acne, or redness, polynucleotide injectables may assist in healing and resilience.

Some individuals benefit from both in a phased treatment plan, under a licensed aesthetic provider’s guidance.

🔗 Consult our clinic to personalise your treatment plan.

Differences in Composition

Injectable Moisturiser: Composed of 100% pure hyaluronic acid, it primarily acts as a hydrator and stimulator for collagen and elastin.

PN Skin Healer: Made from polynucleotides that directly stimulate cellular repair and promote anti-inflammatory effects in the skin.

Differences in Procedure

Injectble Moisturiser: Typically administered in two sessions spaced four weeks apart, Profhilo is injected at specific points on the face, and it quickly disperses across the skin without the need for extensive massage.

PN Skin Healer: Applied through multiple small injections across the treatment area, usually requiring three to four sessions spaced a few weeks apart for optimal results.

Differences in Ideal Candidate

Injectable Moisturiser: Delivers intense hydration, significantly improves skin quality, and increases firmness and elasticity in treated areas. It is particularly effective in providing a natural, youthful appearance without altering facial contours.

PN Skin Healer: Promotes a more comprehensive skin healing process, reducing wrinkles, improving skin barrier function, and minimizing pores. It is highly beneficial for skin with sun damage or signs of premature ageing.

Differences in Side Effects

Injectable Moisturiser: Minimal side effects for injectable moisturiser, typically limited to mild swelling or bruising at the injection sites that resolve within a few days.

PN Skin Healer: The side effects of polynucleotide skin healer are usually minor but can include localised swelling, redness, and bruising, along with the possibility of minor discomfort during injection.

Can both treatments be used together?

Yes, polynucleotides skin healers and injectable moisturisers can be used together in a complementary manner to enhance overall skin rejuvenation.

Each treatment addresses different aspects of skin health and ageing, making them effective when combined.

How Do They Complement Each Other?

Different Targets: Polynucleotide is aimed at cellular repair and improving skin texture by stimulating collagen production through its polynucleotide-based formula. Injectable moisturiser, on the other hand, provides deep hydration and promotes skin elasticity due to its high concentration of hyaluronic acid.
Synergistic Effects: When used together, injectable moisturiser can enhance the hydration and elasticity of the skin, creating a better environment for PN skin healer to promote cellular repair and collagen synthesis. This combination can lead to more comprehensive anti-ageing effects, addressing both surface hydration and deeper skin renewal.
Staggered Treatments: To maximise benefits, treatments can be staggered. For example, a patient might receive an injectable moisturiser treatment to prepare and hydrate the skin, followed by a PN skin healer a few weeks later to promote healing and regeneration.

Frequently Asked Questions

1. Can these treatments be combined?
Yes, they may be part of a combined protocol depending on your skin goals. Professional consultation is required.

2. Is there downtime?
Mild swelling or redness at injection sites is common but temporary. Most people resume normal activity shortly after.

3. Which treatment lasts longer?
Durability depends on skin condition, treatment area, and lifestyle. Maintenance is typically recommended every 6–9 months.

4. Are the ingredients safe?
Both HA and polynucleotides are well-studied substances. Treatments should always be administered by a medical professional.

⚠️ Disclaimer

This article is for educational purposes only and does not constitute medical advice. “Profhilo®” and “Rejuran®” are registered trademarks of their respective owners. No endorsement or comparison of branded medical devices is intended. Please consult a licensed medical provider before beginning any treatment.